Bad with iherb: reviews and prices comparison

Section 1: The Ascendancy of iHerb and Dietary Supplements

The digital marketplace has irrevocably transformed consumer behavior, extending its reach into the realm of health and wellness. Within this landscape, iHerb has emerged as a prominent player, offering a vast catalog of dietary supplements (БАДы in Russian), vitamins, minerals, herbs, and other health-related products. This comprehensive collection, coupled with competitive pricing and international shipping capabilities, has propelled iHerb to the forefront of the online supplement industry.

The allure of dietary supplements stems from a confluence of factors, including an increasing awareness of the importance of preventative health, a desire to address nutritional deficiencies, and a growing interest in natural remedies. Modern diets, often characterized by processed foods and busy lifestyles, may lack essential nutrients, leading individuals to seek supplementation. Furthermore, the aging population is increasingly focused on maintaining cognitive function, bone health, and overall vitality, further driving the demand for dietary supplements.

The Russian market has witnessed a significant surge in the popularity of iHerb, largely due to the accessibility and affordability it offers. Traditional brick-and-mortar pharmacies in Russia may offer a limited selection of dietary supplements at higher prices. iHerb, on the other hand, provides access to a global marketplace with a diverse range of brands and formulations, often at considerably lower costs. This price advantage, combined with the convenience of online shopping and home delivery, has made iHerb an attractive option for Russian consumers seeking to improve their health and well-being.

However, the proliferation of dietary supplements and online retailers also presents challenges. Navigating the vast array of products can be overwhelming, and consumers must exercise caution to ensure the quality and safety of the supplements they purchase. It is crucial to research brands, read reviews, and consult with healthcare professionals before incorporating any new supplement into their regimen. Furthermore, understanding the regulatory landscape surrounding dietary supplements is essential to avoid purchasing counterfeit or substandard products.

The success of iHerb in the Russian market underscores the growing importance of online platforms in providing access to health and wellness products. As consumers become increasingly health-conscious and digitally savvy, online retailers like iHerb are poised to play an even more significant role in shaping the future of the supplement industry. This necessitates a greater emphasis on transparency, quality control, and consumer education to ensure that individuals can make informed decisions about their health and well-being.

Section 2: Navigating the iHerb Landscape: A Guide to Popular Supplement Categories

iHerb’s extensive product catalog can be categorized into various supplement types, each addressing specific health needs and concerns. Understanding these categories is crucial for consumers seeking to find the right supplements for their individual requirements.

Vitamins: Vitamins are essential organic compounds that play vital roles in numerous bodily functions. iHerb offers a comprehensive selection of vitamins, including:

• Vitamin D: Crucial for bone health, immune function, and mood regulation. Particularly important in regions with limited sunlight exposure.
• Vitamin C: A powerful antioxidant that supports immune function, collagen production, and wound healing.
• B Vitamins: A group of eight vitamins essential for energy production, nerve function, and cell growth. Commonly taken as a B-complex supplement.
• Vitamin A: Important for vision, immune function, and skin health.
• Vitamin e: An antioxidant that protects cells from damage.

Minerals: Minerals are inorganic substances that are essential for various bodily functions, including bone health, nerve function, and enzyme activity. iHerb offers a wide range of minerals, including:

• Magnesium: Involved in over 300 enzymatic reactions, crucial for muscle function, nerve function, and blood sugar control.
• Calcium: Essential for bone health, muscle function, and nerve function. Often taken in conjunction with vitamin D.
• Iron: Necessary for oxygen transport in the blood. Important for individuals with iron deficiency anemia.
• Zinc: Crucial for immune function, wound healing, and cell growth.
• Potassium: Important for maintaining fluid balance, nerve function, and muscle function.

Herbs and Botanicals: Herbal supplements have been used for centuries to promote health and well-being. iHerb offers a vast selection of herbal supplements, including:

• Turmeric (Curcumin): Known for its anti-inflammatory and antioxidant properties.
• Ashwagandha: An adaptogen that helps the body cope with stress.
• Ginseng: Known for its energy-boosting and cognitive-enhancing properties.
• Milk Thistle: Supports liver health.
• Echinacea: Supports immune function.

Omega-3 Fatty Acids: Essential fatty acids that are crucial for brain health, heart health, and joint health. iHerb offers various sources of omega-3 fatty acids, including:

• Fish Oil: A rich source of EPA and DHA, two essential omega-3 fatty acids.
• Krill Oil: Another source of EPA and DHA, often considered to be more bioavailable than fish oil.
• Flaxseed Oil: A vegetarian source of ALA, an omega-3 fatty acid that the body can convert to EPA and DHA.

Probiotics: Beneficial bacteria that support gut health. iHerb offers a wide variety of probiotic supplements, with different strains and concentrations.

Other Popular Supplements:

• Collagen: Supports skin health, joint health, and bone health.
• Melatonin: A hormone that regulates sleep.
• Creatine: Supports muscle growth and strength.
• CoQ10: An antioxidant that supports energy production.
• Hyaluronic Acid: Supports skin hydration and joint lubrication.

When choosing supplements on iHerb, it is essential to consider your individual health needs, any existing medical conditions, and any medications you are taking. Consulting with a healthcare professional is always recommended before starting any new supplement regimen.

Section 3: Deciphering iHerb Reviews: A Guide to Evaluating Product Feedback

Customer reviews are an invaluable resource when making purchasing decisions on iHerb. However, it is crucial to approach reviews with a critical eye and understand how to effectively evaluate the feedback provided by other users. Not all reviews are created equal, and some may be more reliable and informative than others.

Assessing Review Authenticity:

• Look for Verified Purchases: iHerb often indicates whether a reviewer has actually purchased the product, adding credibility to their feedback. Reviews from verified purchasers are generally more trustworthy.
• Consider the Reviewer’s History: Check if the reviewer has written multiple reviews on iHerb. A user with a long history of writing detailed and thoughtful reviews is more likely to provide reliable feedback.
• Be Wary of Generic or Vague Reviews: Reviews that simply state “Great product!” or “Works well!” without providing specific details may be less helpful. Look for reviews that explain the reviewer’s experience with the product and the benefits they observed.
• Watch Out for Overly Positive or Negative Reviews: Reviews that are excessively enthusiastic or overly critical may be biased. Look for reviews that offer a balanced perspective and acknowledge both the pros and cons of the product.
• Beware of Suspicious Language or Grammar: Reviews with poor grammar, spelling errors, or unusual phrasing may be fake or written by non-native speakers.

Analyzing Review Content:

• Focus on Specific Details: Pay attention to reviews that provide specific details about the product’s effects, such as improvements in energy levels, sleep quality, or skin condition.
• Consider the Reviewer’s Health Condition: Take into account the reviewer’s health condition and whether it is similar to your own. A review from someone with a similar condition may be more relevant to your situation.
• Look for Mentions of Side Effects: Be aware of any potential side effects reported by other users. Even natural supplements can cause side effects in some individuals.
• Compare Reviews from Multiple Sources: Don’t rely solely on reviews on iHerb. Check reviews on other websites and forums to get a more comprehensive picture of the product’s effectiveness and safety.
• Pay Attention to Negative Reviews: Don’t dismiss negative reviews outright. Read them carefully to understand the potential drawbacks of the product.
• Look for Trends: If multiple reviewers mention the same benefits or side effects, it is more likely that those effects are genuine.

Utilizing iHerb’s Review Features:

• Sort Reviews by Rating: You can sort reviews by rating to quickly identify the highest-rated and lowest-rated reviews.
• Filter Reviews by Language: If you prefer to read reviews in Russian, you can filter the reviews by language.
• Use the “Helpful” Button: iHerb allows users to mark reviews as “helpful.” Pay attention to reviews that have been marked as helpful by other users.
• Ask Questions: If you have specific questions about a product, you can ask them in the comments section of the product page.

By carefully evaluating iHerb reviews, you can gain valuable insights into the effectiveness and safety of dietary supplements. Remember to approach reviews with a critical eye and consider multiple sources of information before making a purchasing decision. Consulting with a healthcare professional is always recommended before starting any new supplement regimen.

Section 4: Price Comparison Strategies on iHerb: Maximizing Value and Savings

iHerb is known for its competitive pricing, but strategic shopping can further enhance value and savings. Understanding price comparison techniques and leveraging iHerb’s features can significantly reduce the cost of dietary supplements.

Direct Price Comparison:

• Compare Prices Across Brands: iHerb offers a wide range of brands for many supplements. Compare the prices of similar products from different brands, considering factors such as dosage, ingredients, and quality.
• Check Prices in Different Quantities: Supplements are often available in various sizes and quantities. Calculate the price per serving or unit to determine the most cost-effective option.
• Consider Subscribe & Save: iHerb’s Subscribe & Save program offers discounts on recurring orders. If you regularly purchase a particular supplement, subscribing can save you a significant amount of money.
• Watch for Sales and Promotions: iHerb frequently runs sales and promotions on various products. Keep an eye out for these deals to save even more.

Indirect Price Comparison:

• Compare Prices with Local Retailers: Before purchasing a supplement on iHerb, compare the price with local pharmacies and health food stores. While iHerb often offers lower prices, it’s always a good idea to verify.
• Factor in Shipping Costs: Shipping costs can vary depending on the weight and destination of your order. Be sure to factor in shipping costs when comparing prices.
• Consider Customs and Import Duties: Depending on your location, you may be subject to customs and import duties on your iHerb order. These fees can add to the overall cost of the supplement.
• Account for Currency Exchange Rates: If you are paying in a currency other than US dollars, be aware of the current exchange rate. Currency fluctuations can affect the final price of your order.

Leveraging iHerb Features for Savings:

• Use iHerb Promo Codes: iHerb often offers promo codes that can be applied to your order for additional discounts. Look for promo codes online or in email newsletters.
• Take Advantage of Loyalty Programs: iHerb may offer loyalty programs that reward customers for repeat purchases. These programs can provide discounts, free shipping, or other benefits.
• Refer Friends: iHerb’s referral program allows you to earn rewards by referring friends to the website. When your friends make a purchase, you will receive a commission.
• Check the “Specials” Section: iHerb has a “Specials” section that features discounted products. This is a great place to find bargains on a variety of supplements.
• Use the iHerb App: The iHerb app often offers exclusive deals and discounts that are not available on the website.
• Utilize the “Clearance” Section: Iherb has a clearance section that often lists products near their expiration date at significantly reduced prices. Consider these options if you plan to use the supplements immediately.

Additional Tips for Saving Money:

• Buy in Bulk: Purchasing larger quantities of supplements can often result in lower prices per serving.
• Consider Generic Brands: iHerb offers a variety of generic or store-brand supplements that are often less expensive than name-brand products.
• Read Product Labels Carefully: Ensure that you are getting the correct dosage and ingredients for your needs. Avoid purchasing supplements with unnecessary additives or fillers.
• Avoid Impulse Purchases: Stick to your shopping list and avoid purchasing supplements that you don’t need.

By following these price comparison strategies and leveraging iHerb’s features, you can maximize value and savings on your supplement purchases. Remember to always prioritize quality and safety when choosing supplements, and consult with a healthcare professional before starting any new supplement regimen.

Section 5: Quality Assurance and Safety Considerations: Navigating the Risks of Online Supplement Purchases

While iHerb provides access to a vast array of supplements, ensuring product quality and safety is paramount. The supplement industry, particularly online, faces challenges related to regulation, quality control, and potential adulteration. Consumers must be proactive in mitigating these risks to safeguard their health.

Understanding the Regulatory Landscape:

• Supplement Regulation in the US: In the United States, dietary supplements are regulated by the Food and Drug Administration (FDA) under the Dietary Supplement Health and Education Act of 1994 (DSHEA). Unlike drugs, supplements are not subject to pre-market approval by the FDA. This means that manufacturers are responsible for ensuring the safety and efficacy of their products, but the FDA does not independently verify these claims before they are sold.
• GMP Certification: Good Manufacturing Practices (GMP) are a set of standards that ensure that supplements are manufactured in a consistent and controlled manner. Look for supplements that are GMP-certified by reputable organizations such as NSF International, USP, or Informed-Sport. GMP certification indicates that the manufacturer has implemented quality control measures to ensure the identity, purity, strength, and composition of the supplement.
• Third-Party Testing: Third-party testing involves independent laboratories analyzing supplements to verify their ingredients and potency. Look for supplements that have been tested by third-party organizations to ensure that they meet label claims and are free from contaminants.
• Russian Regulations (ТР ТС 021/2011 and other relevant regulations): Understand that supplements sold in Russia need to adhere to Eurasian Economic Union regulations like TR TS 021/2011 (“On Food Safety”). Look for products that indicate compliance with these regulations, although confirmation can be difficult for products purchased outside of Russia.

Identifying Potential Risks:

• Adulteration: Adulteration is the practice of adding undeclared ingredients to supplements, such as prescription drugs, synthetic chemicals, or heavy metals. Adulterated supplements can pose serious health risks.
• Contamination: Supplements can be contaminated with bacteria, mold, pesticides, or other harmful substances during manufacturing or storage.
• Incorrect Labeling: Some supplements may have inaccurate labels that do not accurately reflect the ingredients or potency of the product.
• False Claims: Manufacturers may make false or misleading claims about the health benefits of their supplements.
• Counterfeit Products: Counterfeit supplements are fake products that are designed to look like genuine supplements. Counterfeit supplements may contain harmful ingredients or no active ingredients at all.

Mitigating Risks and Ensuring Safety:

• Choose Reputable Brands: Stick to well-known and reputable brands that have a track record of quality and safety. Research brands before purchasing their products.
• Read Labels Carefully: Carefully read the product label to understand the ingredients, dosage, and potential side effects.
• Look for Certifications: Look for supplements that are GMP-certified and have been tested by third-party organizations.
• Check for Recalls: Check the FDA website for recalls of dietary supplements.
• Consult with a Healthcare Professional: Consult with a doctor, pharmacist, or registered dietitian before starting any new supplement regimen. They can help you choose safe and effective supplements and advise you on potential interactions with medications.
• Report Adverse Events: If you experience any adverse events after taking a supplement, report them to the FDA’s MedWatch program.
• Be Skeptical of Unrealistic Claims: Be wary of supplements that make unrealistic claims about curing diseases or providing dramatic health benefits.
• Purchase from Trusted Sources: Buy supplements from reputable online retailers like iHerb and avoid purchasing from unknown or untrusted sources. Verify iHerb’s seller ratings and customer feedback.
• Check Expiration Dates: Always check the expiration date of supplements before taking them. Do not take supplements that have expired.

Specific Considerations for iHerb Purchases:

• Review Seller Ratings: Pay close attention to seller ratings and reviews on iHerb. Choose sellers with high ratings and positive feedback.
• Check Product Authenticity: If you suspect that a product may be counterfeit, contact iHerb customer service for assistance.
• Be Aware of International Shipping: Be aware that supplements shipped from overseas may be subject to different regulations than those sold in your country.

By taking these precautions, consumers can minimize the risks associated with purchasing supplements online and ensure their safety and well-being. Remember that dietary supplements are not a substitute for a healthy diet and lifestyle. They should be used as part of a comprehensive approach to health and wellness.

Section 6: Specific Supplement Reviews and Comparisons: Popular Choices on iHerb

This section provides detailed reviews and comparisons of several popular supplements commonly purchased on iHerb. These examples illustrate how to critically evaluate product information and customer feedback.

1. Solgar Vitamin D3 5000 IU:

• Description: Solgar is a well-known brand known for its high-quality supplements. This product provides a high dose of Vitamin D3 (cholecalciferol), the form of Vitamin D that is most easily absorbed by the body.
• Claims: Supports bone health, immune function, and mood regulation.
• Ingredients: Vitamin D3 (as cholecalciferol), cellulose, vegetable cellulose, vegetable magnesium stearate.
• Pros: Reputable brand, high potency, vegetarian-friendly.
• Cons: High dose may not be suitable for everyone, relatively expensive compared to some other brands.
• Reviews: Reviews often highlight the product’s effectiveness in raising Vitamin D levels, particularly in individuals with deficiencies. Some reviewers note the relatively large size of the softgels.
• Comparison: Compared to other Vitamin D3 supplements on iHerb, Solgar is generally considered to be a premium option. Lower-priced alternatives may be available, but may not offer the same level of quality or potency. Consider brands like Now Foods or Healthy Origins for more budget-friendly options. Check for certifications such as USP or NSF.

2. California Gold Nutrition Gold C Vitamin C:

• Description: A popular Vitamin C supplement from iHerb’s own brand, California Gold Nutrition. Contains ascorbic acid, a common form of Vitamin C.
• Claims: Supports immune function, antioxidant protection, and collagen production.
• Ingredients: Vitamin C (as ascorbic acid), modified cellulose (vegetarian capsule), silicon dioxide.
• Pros: Affordable price, vegetarian-friendly, readily available.
• Cons: Ascorbic acid may be irritating to some individuals, especially at high doses.
• Reviews: Reviews generally praise the product’s affordability and effectiveness. Some reviewers report experiencing mild stomach upset at higher doses.
• Comparison: Compared to other Vitamin C supplements, California Gold Nutrition Gold C is a budget-friendly option. Buffered forms of Vitamin C, such as sodium ascorbate or calcium ascorbate, may be better tolerated by individuals with sensitive stomachs. Brands like Ester-C are more expensive but may offer better tolerability.

3. Now Foods Magnesium Citrate:

• Description: A magnesium supplement in the form of magnesium citrate, which is generally well-absorbed.
• Claims: Supports muscle function, nerve function, and relaxation.
• Ingredients: Magnesium (from magnesium citrate), cellulose, magnesium stearate (vegetable source), silica.
• Pros: Affordable price, easily absorbed form of magnesium.
• Cons: Magnesium citrate can have a laxative effect in some individuals.
• Reviews: Reviews often mention the product’s effectiveness in improving sleep quality and reducing muscle cramps. Some reviewers report experiencing diarrhea or loose stools.
• Comparison: Compared to other magnesium supplements, magnesium citrate is a common and affordable option. Other forms of magnesium, such as magnesium glycinate or magnesium threonate, may be better tolerated and offer specific benefits. Magnesium glycinate is often preferred for sleep and relaxation, while magnesium threonate may be beneficial for cognitive function.

4. Doctor’s Best Curcumin with BioPerine:

• Description: A turmeric supplement containing curcumin, the active compound in turmeric, and BioPerine (black pepper extract) to enhance absorption.
• Claims: Supports healthy inflammation response, joint health, and antioxidant protection.
• Ingredients: Curcumin C3 Complex (from Curcuma longa rhizome), BioPerine black pepper extract (from Piper nigrum fruit), modified cellulose (vegetarian capsule), cellulose, magnesium stearate (vegetable source), silicon dioxide.
• Pros: Contains BioPerine to enhance absorption, vegetarian-friendly, reputable brand.
• Cons: Relatively expensive compared to some other turmeric supplements.
• Reviews: Reviews frequently mention the product’s effectiveness in reducing joint pain and inflammation. The inclusion of BioPerine is often cited as a key benefit.
• Comparison: Compared to other turmeric supplements, Doctor’s Best Curcumin with BioPerine is a popular and well-regarded option. Look for supplements with standardized curcuminoid content (e.g., 95% curcuminoids) and enhanced absorption. Consider other brands like Thorne Research or Life Extension for premium options.

5. Nature’s Way Ashwagandha:

• Description: An ashwagandha supplement, an adaptogenic herb that helps the body cope with stress.
• Claims: Supports stress management, energy levels, and cognitive function.
• Ingredients: Ashwagandha (root), plant-derived capsule (hypromellose), magnesium stearate.
• Pros: Affordable price, widely available, reputable brand.
• Cons: May not be suitable for individuals with thyroid issues.
• Reviews: Reviews often mention the product’s effectiveness in reducing stress and anxiety. Some reviewers report improved sleep quality and energy levels.
• Comparison: Compared to other ashwagandha supplements, Nature’s Way Ashwagandha is a budget-friendly option. Look for supplements with standardized Withanolide content (e.g., 2.5% Withanolides) for consistent potency. Sensoril Ashwagandha is a patented form of ashwagandha that is often considered to be more potent and effective.

These reviews and comparisons highlight the importance of considering factors such as brand reputation, ingredients, dosage, reviews, and price when choosing supplements on iHerb. Remember to consult with a healthcare professional before starting any new supplement regimen.

Section 7: Potential Drug Interactions and Contraindications: A Critical Safety Check

Dietary supplements, while often perceived as natural and safe, can interact with medications and may be contraindicated for certain individuals with pre-existing health conditions. Understanding these potential risks is crucial to prevent adverse health outcomes. Always consult with a healthcare professional before combining supplements with any medications or if you have any underlying health conditions.

Common Supplement-Drug Interactions:

• Vitamin K and Warfarin (Coumadin): Vitamin K can interfere with the anticoagulant effects of warfarin, a blood-thinning medication. Individuals taking warfarin should maintain a consistent intake of Vitamin K-rich foods and supplements.
• St. John’s Wort and Antidepressants/Other Medications: St. John’s Wort, an herbal supplement used for depression, can interact with a wide range of medications, including antidepressants, birth control pills, and HIV medications. It can reduce the effectiveness of these medications or increase the risk of side effects.
• Ginkgo Biloba and Blood Thinners: Ginkgo Biloba, an herbal supplement used to improve cognitive function, can increase the risk of bleeding when taken with blood-thinning medications such as aspirin, warfarin, or clopidogrel.
• Garlic and Blood Thinners: Garlic, both in food and supplement form, can have blood-thinning effects. It should be used with caution in individuals taking blood-thinning medications.
• Iron and Thyroid Medications: Iron supplements can interfere with the absorption of thyroid medications. It is recommended to take iron supplements at least four hours apart from thyroid medications.
• Calcium and Certain Antibiotics: Calcium supplements can interfere with the absorption of certain antibiotics, such as tetracycline and quinolone antibiotics. It is recommended to take calcium supplements at least two hours before or after taking these antibiotics.
• Grapefruit Juice and Various Medications: Grapefruit juice can interact with a wide range of medications, including statins (cholesterol-lowering drugs), calcium channel blockers (blood pressure medications), and certain antidepressants. It can increase the levels of these medications in the blood, leading to increased side effects.
• Melatonin and Antidepressants/Other Sedatives: Melatonin, a hormone that regulates sleep, can interact with antidepressants and other sedatives. It can enhance the sedative effects of these medications.
• Coenzyme Q10 (CoQ10) and Blood Pressure Medications: CoQ10 can lower blood pressure. Individuals taking blood pressure medications should monitor their blood pressure closely when taking CoQ10.
• Omega-3 Fatty Acids and Blood Thinners: High doses of omega-3 fatty acids can have blood-thinning effects. Individuals taking blood-thinning medications should use omega-3 supplements with caution.

Contraindications for Specific Health Conditions:

• Individuals with Thyroid Issues: Certain supplements, such as ashwagandha and iodine, can affect thyroid function. Individuals with thyroid issues should consult with their doctor before taking these supplements.
• Individuals with Kidney Disease: Some supplements, such as creatine and high doses of Vitamin C, can be harmful to individuals with kidney disease.
• Pregnant and Breastfeeding Women: Many supplements are not safe for pregnant or breastfeeding women. It is essential to consult with a healthcare professional before taking any supplements during pregnancy or breastfeeding.
• Individuals with Autoimmune Diseases: Certain supplements, such as echinacea and astragalus, can stimulate the immune system and may not be suitable for individuals with autoimmune diseases.
• Individuals with Liver Disease: Some supplements, such as milk thistle and kava, can be harmful to the liver. Individuals with liver disease should consult with their doctor before taking these supplements.
• Individuals Undergoing Surgery: Certain supplements, such as garlic, ginkgo biloba, and Vitamin E, can increase the risk of bleeding during surgery. It is recommended to stop taking these supplements at least one to two weeks before surgery.

General Recommendations:

• Disclose Supplement Use to Your Healthcare Provider: Always inform your doctor, pharmacist, or registered dietitian about all the supplements you are taking, including vitamins, minerals, herbs, and other dietary supplements.
• Research Potential Interactions: Before starting any new supplement, research potential interactions with your medications and health conditions.
• Start with Low Doses: When trying a new supplement, start with a low dose and gradually increase it as tolerated.
• Monitor for Side Effects: Pay attention to any side effects you experience after taking a supplement. If you experience any unusual or concerning symptoms, stop taking the supplement and consult with your doctor.
• Be Wary of Combination Products: Combination products that contain multiple ingredients may increase the risk of interactions and side effects.
• Purchase from Reputable Sources: Buy supplements from reputable retailers like iHerb and avoid purchasing from unknown or untrusted sources.
• Consult with a Qualified Healthcare Professional: Always consult with a qualified healthcare professional before starting any new supplement regimen, especially if you are taking medications or have any underlying health conditions. They can provide personalized advice based on your individual needs and health status.

By understanding the potential drug interactions and contraindications of dietary supplements, individuals can make informed decisions about their health and prevent adverse health outcomes. Safety should always be the top priority when considering supplement use.